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KMID : 0921620200500030175
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Journal of Bacteriology and Virology
2020 Volume.50 No. 3 p.175 ~ p.180
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Recent Research and Knowledge on Treatment for Hepatitis B
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Lee Hye-Won
Choi Yong-Wook
Park Yong-Kwang
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Abstract
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Hepatitis B virus (HBV) infection is a major public health problem, with some 250 million people currently at high risk of developing chronic liver diseases. The current antiviral treatment for chronic hepatitis B (CHB) is effective in controlling viral replication but fails to achieve a complete cure. Since the identification of sodium taurocholate cotransport polypeptide (NTCP) as an HBV receptor, anti-HBV drugs targeting viral entry, capsid assembly, cccDNA, transcription, and secretion have been developed. In this paper, the potential inhibitors in various steps of the HBV life cycle are summarized.
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KEYWORD
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Hepatitis B virus, Drugs, cccDNA, ISG20
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